Simian 2.2 PRO __EXCLUSIVE__

Simian 2.2 PRO __EXCLUSIVE__

Simian 2.2 PRO ::: https://byltly.com/2taPHX

Paired box factors (PAX factors) are transcription factors that act as heterodimers by binding to specific DNA sequences in promoters and enhancers of other genes [55–58]. The interaction of PAX factors with each other regulates cell-type specification and tissue-specific gene expression in a variety of systems [55–62]. The most thoroughly characterized among these transcription factors is the Paired Box gene 2 (Pax2) (Pax2) that controls the development of the pancreas [63]. The mouse Pax2 coding sequence (CDS) encodes a protein of 312 amino acids [63]. Our alignment of the Pax2 CDS from several divergent mammalian species revealed that the coding region of this gene is highly conserved, except for a 26-amino-acid region, which is subject to positive selection (Additional file 1: Table S2). The TGGAPG core promoter binding site is located in the conserved region, and the Pax2 expression is driven by this conserved promoter [54]. Human PAX2 is known to activate the transcription of human insulin [64] and pancreatic and duodenal homeobox 1 (PDX1) genes in mice [65]. In the pancreas, Pax2 is transiently expressed in the progenitor cells and subsequently replaced by the continuous expression of the PDX1 gene [66]. Therefore, the conserved amino acid region of Pax2 is likely to be important for the activation of Pax2 promoter. Because the conserved region contains the TGGAPG core promoter motif, it is possible that the activation of Pax2 is regulated by other PAX family members in a tissue-specific manner. In humans, mutations in PAX2 are associated with congenital heart defects, particularly aortic coarctation [67].

This paper reports a case-control study of a group of Iranian patients with diffuse malignant mesothelioma. Patients enrolled in the study included those from 1) Khorasan region where there is a high prevalence of the disease and 2) those from Mashhad, the capital of Khorasan province, where no case-control study had been conducted thus far. Simian virus 40 (SV40) DNA was detected in 63% of the patients' tumors versus 43% of the controls by PCR and Southern blotting. The odds ratio of developing mesothelioma after an infection with SV40 was 4.4 (95% CI, 2.1 to 10.1), P value for trend = 0.001. There was no association between SV40 and histological subtypes of mesothelioma, but the odds ratio was significant in pleural mesothelioma for SV40-positive patients versus SV40-negative patients in both regions (3.9, 95% CI, 1.0 to 14.5).

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